Understanding Metabolomics
Molecular Portrait of the Biological System
Metabolomic concepts
Molecules Closest to Phenotypes

Metabolomics studies the relationship between metabolite changes and phenotypes in living organisms under certain physiological conditions or in response to external stimuli in order to understand the underlying mechanisms of disease occurrence and development.

Metabolomics can act as a link between genetics and environmental exposures, revealing the origins of phenotypes in different people. Metabolite perturbation can more sensitively respond to changes in organism state and phenotypic differences, and is the most direct molecular basis for macroscopic phenotypic changes.

Metabolites are found in all types of biological samples, and the basic metabolic pathways are shared by even the most dissimilar species. Metabolomics research focuses not only on all metabolites in the body, but also on the various factors that regulate metabolism. As a result, metabolomics is appropriate for related research and applications involving the human body, food consumed by the human body, and microorganisms that interact with the human body.


Development of Metabolomics
Metabolomics is a Rapidly Growing Discipline

It has been developing rapidly since the mid-1990s.

To-date, this technology is becoming more precise and efficient.

The earliest use of ants in human urine to diagnose diabetes

5th to 6th century AD
1913

The mass spectrometry method was first invented by J.J.Thomson, and later improved by FW.Aston et al

Biological metabolism including ornithine cycle, tricarboxylic acid cycle and glyoxylate cycle were proposed

1932
1999
Jeremy K. Nicholson of Imperial College London first proposed the term "metabolome“
KEGG bioinformatics database, mainly focusing on metabolic pathways and integrating metabolic, gene and protein pathways
2000
2004
The Human Metabolome Project (HMP) begins

The HMDB database is recognized as the standard metabolomics resource for human metabolism research (continuously updated)

2007
2009

Nature published the research results of metabolomics applied to prostate cancer biomarkers (sarcosine)

Metabolomics study found TMAO to be an independent predictor of cardiovascular disease
2011
2016
China's precision medicine plan was proposed to accelerate metabolomics research to discover medical biomarkers
large-scale cohorts, multi-omics, big data and Al expanding the field of metabolomics
Since the 21st century
Fields of Application
Metabolomics is Closely Related to Human Health and Daily Life

Metabolomics has rapidly developed and penetrated many fields, demonstrating its strong application potential.

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